China Traditional Medicine

Posts Tagged ‘Evodia’

2.3.5. Antidiarrheal effect:.

2.3.5.1. On castor oil induced diarrhea in mice of 36 male and female mice, weighing 20.7 ± 2.6g, were divided into 3 groups and were fed water Evodia Decoction, 30 minutes after the enema castor oil 0.15ml / only record the number of diarrhea. Fasting during the experiment the water. Evodia 10g and are visible 20g/kg number of diarrhea caused by reduction of castor oil, and as the dose increases the duration of effect, but the effect is produced slowly.

2.3.5.2. Senna induced diarrhea in mice on the impact of 30 male and female mice, weighing 19.2 ± 1.8g, were divided into 3 groups, respectively, Evodia Decoction enema and running water for 30 minutes senna enema 0.4g / only observe the number of diarrhea, a total of 8 hours. Evodia visible role against diarrhea caused by senna increases with the dose increased, although the role of slow production, but longer duration.

3. On the late effects of hemorrhagic shock: 22 rabbits, either sex, weight 1.75 ± 0.25kg, imitation Wiggers replicated with advanced storage Xueping rabbit model of hemorrhagic shock. In whole blood transfusion from the ear after intravenous administration. Evodia Decoction treatment group for injection (normal saline diluted to 0.5g/ml) 10ml/kg; 4 drops / min, 3 ?? drops End; control group was given normal saline, observed 3 hours, 6 hours survival rate, mean arterial blood pressure, heart rate and urine output. Results and saline control, Evodia Decoction shock quickly and significantly increased blood pressure in rabbits, and blood pressure slow down later, no significant effect on heart rate. 3 hours after administration of the treatment group survival rate was 11/11 was significant (P <0.05), higher than the 6 / 11; 6h survival rate was 7 / 11, there was significant (P <0.05) higher than 1 / 11. Urine of rabbits after blood loss is significantly reduced, compared with the control group, a significant increase in urine output Evodia soup. After administration, the treatment group breathing, heart rate change from the weak clear, limb shaking; control rabbits breathing, heart rate is still weak, the body lying on.

4. On thrombosis and coagulation effect: Wister rats 60, male and female, weight 185 ± 25g, were randomly divided into 6 groups, control group was given equal volume of saline; Evodia water extract group, according to 1 LD50 / 5,1 / 10,10-20g / kg oral administration, the other two groups for the tuber water extract group. 1 hour after administration to determine the time of thrombosis and blood biochemical determination of the project. Heparin, intravenous l00u/kg, spend method. Results in the aqueous extract of Evodia 20g/kg doses, thrombus formation time was prolonged; in 10g/kg dose, kaolin partial thromboplastin time (KPTT) have different degrees of extension, 20g/kg dose, KPTT, VF was extended. No significant changes in other indicators.

5. Hepatoprotective effect: acute liver injury induced by CCl4 in rats of SGPT and SGOT of 36 male and female rats, weight 222 ± 25g, sharing four groups were administered l times a day Evodia Decoction and tap water, continuous 5 days, 1 hour after the last administration, in addition to water control group, other groups were injected carbon tetrachloride (CCl4) 0.3ml/kg, and fasting for 16 hours under urethane anesthesia in carotid artery blood measured SGPT and SGOT. Evodia 5 and 10g/kg can be seen against the role of CCl4 increased SGPT, which 5g/kg groups can not fight the role of CCl4 increased SGOT.

6. Other effects: Evodia 20g/kg mice by oral decoction, can significantly reduce the antimony potassium tartrate writhing response induced by hot-plate number and extension of the pain stimulus response latency. It was reported that the methanol and water Evodia extracts have 5 – HT receptor affinity, indirect evodiamine dehydrogenase may be prompted to 5 – hydroxytryptamine receptor agonist. According to another report, the ethanol extract of Evodia fruits of Chinese hamster lung cells (V-79) had a significant effect. Isolated from the plant cytotoxin yellow powder. With the V-79 cells by the cytotoxicity assay, only this yellow powder showed significant activity. In a further use of tumor cells, human nasopharyngeal carcinoma (KB) and mouse lymphocytes, leukemia cells (P388), by the cytotoxicity assay, also showed activity only this yellow powder. Their IC50 values ??were: V-79 is 0.19mg/ml; KB was 0.98mg/ml; P388 is 0.43mg/ml. In addition, Evodia fruit have anti-hypoxia effect evodiamine.

? ?Identify physical and chemical identification of this product powder 0.5g, adding hydrochloric acid solution (l ? 100) 10ml, shake vigorously for several minutes, filtration. ? The filtrate 2ml, potassium iodine test solution 1 drop of mercury, after shaking, the resulting yellow-white precipitate. (Check the alkaloids) ? In another filtering 1ml, slowly adding to the test solution dimethylamino benzaldehyde 2ml, heated on a water bath, the two liquid junction formation at the ring with a reddish brown. (Check the indole alkaloids) sub-standard goods big grain pellets EC goods and cargo system. Large grain cargo system: five were spherical flat edges, the surface dark brown, top of the more than five gap, rich aroma. Pellets EC goods: cylindrical spherical lobes is not obvious, green or gray-green surface, a light fragrance.

Evodia processing? ?Sunburn: Take licorice decoction, to Java to take soup, added a net Evodia, soaking liquid to the dry soup for the degree, Wei Huo drying. (Per Evodia 100 pounds, 6 pounds 4 with licorice two).

? ?Taste Xin; bitter; heat; small drug

?? Liver Meridian; stomach; spleen; colon; kidney

?Indication? and cold pain; Shugan lower gas; temperature in the dampness. The main abdominal abdominal Leng Tong; Jueyin headache; colic; athlete’s foot swelling; Tunsuan vomiting, cold diarrhea

Dosage Oral: Jiantang ,1.5-5g; or into pills, powder. External use: moderate, Yan Mo deposited transfer, or fried Washed.

?Note?

1.

2. “Ben Cao Meng Quan”: false intestine, especially those who avoid leakage.

3. “Compendium of Materia Medica”: take the gas, flare, faint eyes, hair sores.

4. “Ben Cao Jing Shu”: vomiting, stomach fire Tunsuan is who should not use; Keni on the gas, and non-cold evils and cold due to phlegm places who should not use water; abdominal pain is a deficiency of blood and fire who should not use; Chibai diarrhea due to summer heat evil into the stomach, rather than the food and drinks cold, stagnant fouling who should not use; intestinal hernia, non-sudden sense of cold evil, and the initial issuance of one or two who should not use; cholera Zhuan tendons, due to the weak spleen and stomach to take summer cause, rather than committing alpine cold stomach who should not use; all the Yin of the card and the internal organs were hot without cold, avoid salty law.

? ?Each paper

1. “Materia Medica Yan Yi”: Evodia steepest under the gas, intestinal virtual personal services of even worse.

2. “Medical Kai source”: “attending secret” cloud, (Evodia) flotation down the taste, the use of four: go to a chest cold too; only hurts the second also; feeling cold abdominal pain, three also; consumer hangover, White cardamom is also the junior four.

3. Wang Hao Gu: red veins for the disease, against the gas in the acute and wish to use (Evodia) Lord. Therefore Zhongjing Evodia soup, soup side rule Dangguisini Jue Yin disease the organs, all with this also.

4. “Compendium of Materia Medica”: Cornel, Xin heat dispersion can be warm, dry heat can be hard strong, so the rule permits, whichever is both warm and cold, the dampness Jieyu the power only. Tongue sore throat were, to the end of Vinegar cornel, posted two Zuxin, the more the night shift. Although the nature of heat, but can lead heat down, cover is also from the administration of justice, and that the nature of upstream cornel no less than entrants, might otherwise have. Some people who Koujin of infant smallpox, Nie cornel one, two of which means that the wipe is also whichever Xinsan ears.

5. “Ben Cao Jing Shu”: Where the spleen and stomach gas, thermophilic and aversion to cold, cold is in the air can not be shipped, or for real Needless to cold, or abdominal cramps, or Han Tan stop product, so that gas against fat Well, the five internal organs negative. Evodia, Han Xie Xin warm stomach and dispersed, then the self-temperature, gas from the next, and all proof Xichu. The main dehumidification blood weakness, by Feng Xie who, covered with wind cold dampness of the evil, and more from the stomach into the room, the main stomach muscles, for the evil of the invasion, the Cou closed dense, and cold and heat are never carry all Bi, Xin Wen become separated from development, it can wind cold dampness of the evil, from the Cou out. The evil abdominal pain, also committed the spleen and stomach gas caused by evil, Rupi San evil, the pain from just carry on.

6. “Materia Medica words”: Evodia, Gloomy of stagnation, by the cold air of the drug also reduced. Dragon Fang said, all suffering from the lower abdomen, lower abdomen chill of the disease, or against the nausea and vomiting Tunsuan spit acid, or close together but separated from fresh sputum cells separated gas, diarrhea or stomach stop Haner self, or liver and spleen Stagnation The fullness against food, or gas and the attack string hernia Zheng Jia cited the lower abdomen, or vomit ? beriberi Suanku red heart, liver, spleen and kidney are all the cards have been, Evodia can be rule.

7. “This by every original”: Cornel good, and so the service Zhuyu who have rushed diaphragm red eyes, hair loss, sore throat, sores made victims of hot work. Note under the weight of its governing violence, vomit against Tunsuan, liver and spleen fire against the certificate, the will and the bitter cold of dynasties, as following Kanemaru sputum transport noisy anger rule the most effective.

8. “Materia Medica will read”: Evodia, hard and warm, aromatic and dry, the main drugs of the liver, and stomach and into those of Hong dry hi spleen, stomach and hi down also. Lower gas most of its speed, extremely loose knot can be declared, so the liver qi stagnation rule, squat under cold cloud, which refer, abdominal pain, hernia and other diseases, or Evils very down on, is for the vomiting Tunsuan chest full of various diseases, can be rule. That is the nature of their hard work in Hong dry, almost could imagine the power. What, then Liver treatment and the lower stomach damp stagnation and dirty, all appropriate ears.

9. “Shen Nong Ben Cao Jing”: the main lower temperature gas, pain, Keni cold and heat, dehumidification blood weakness, by Feng Xie, open Cou.

10. “Doctors do not record”: the main cold phlegm, abdominal cramps, cold reality Needless to all, the evil, heart pain, reverse air, Lee five internal organs.

11. “Medicinal”: the main confidant of disease, volume of cold, the heart under the knot gas, Zhu heartache; treatment of cholera transferred tendons, stomach air-conditioning, abdominal pain, vomiting and diarrhea can not win the ninja; treatment Bianshen stubborn weakness, cold Needless, Lee colon owned gas .

12. “Herbal Supplements”: kill the evil worm drugs, dental moth-eaten.

13. “Japan Hanako Materia Medica”: spleen through joints. Treatment of abdominal pain, kidney, beriberi, edema, lower than postpartum blood.

14. Wang Hao Gu: Cypriot administration chest fullness, pharyngeal diaphragm barrier, run dry liver spleen.

15. “Compendium of Materia Medica”: Gloomy of stagnation. Governance Tunsuan, hold the spit Jueyin headache, insidious abdominal pain, hernia, Campylobacter, mouthpiece of the ulcer.

Extract? ?”Chinese Materia Medica”

 

?? Habitat distribution

Environment: 1. Grown in low elevation forests on the sunny woodland edge or under the open areas.

2. Born in the hillside grass.

3. Born in the village side street, the grass slopes.

Distribution of resources: 1. Located in Shaanxi, Gansu, Anhui, Zhejiang, Fujian, Taiwan, Hubei, Hunan, Guangdong, Guangxi, Sichuan, Guizhou, Yunnan.

2. Distributed in Zhejiang, Jiangxi, Hubei, Hunan, Guangxi, Sichuan, Guizhou.

3. Distributed in Jiangxi, Hunan, Guangdong, Guangxi and Guizhou.

?Culture?

Hi biological characteristics of warm and humid climate, cold intolerance, dry. To choose a sunny, deep, loose and fertile, well-drained sandy loam soil and humus on the cultivation of appropriate; low-lying ground water should not be cultivated.

Cultivation techniques using seed, tiller, cutting propagation. Seed Propagation: Take Shushi robust results and more plants to be closed later ripening, dry out and avoid the sun, or easy to make seeds lost germination ability. Spring, in late March early April -4, interpolation of Use, spaced 15-20cm by open ditch, deep 3-5cm, broadcast the seed evenly into the thin cover of fine soil, Gallant layer of water moisture. Is due to slow reproduction, the production has been put to use less. Division propagation: 12 months late, from 0.6m in the mother plant at the side, away with the lateral root of the table, exposing coarse lateral roots, at intervals of about 7cm cut a wound, then cover soil, manure applied. Director of a wound spring, seedlings, seedlings grow up to be, and the mother plants can be separated. Propagation: branch interpolation, 11-12 months or 1-2 months before the plants sprout, clipping branches to 1-2 year old cuttings robust, long 20-25cm, with 3-4 buds, both ends of the cut slope, cutting hand bed, above the ground 5-10cm, straw floor, pay attention to watering and shading. Cuttings root in about 1-2 months. 2nd year seedling transplanting 30cm. Root cuttings, and election 4-6 years old, early in February after the election than the thick lateral roots, cut into small pieces for 15-18cm cuttings, by row spacing 15cm × 15cm open hole, Xiecha per hole section of casing, pouring water. Seedlings can be transplanted the second year, planting or transplanting time, March-April November-December, according to the line beads from (1.5-2) m × (1.5-2) m open hole, hole diameter 60cm, depth 45cm, composting manure was applied to seedlings planted roots after dipping yellow mud, casing, compaction, watering.

Field cultivation, weed management each year, with top dressing applied 2-3 times a topdressing in early spring before budding human waste, bud before the Zaishi 1. After flowering by phosphorus, potassium, prevent fruit drop, and promote full seed maturity. And training, young tree topping at 80cm from the ground, prompting the formation of certain crown; adult trees to be cut off overlapping branches, drooping branches, twigs, worms, branches, old and weak branches. Leaves can be trimmed after work. And to earth warm antifreeze. After transplanting young trees can be interplanted between rows of peanut, potato, soybean, or pyrethrum and so on.

Pest control sooty mold disease has killed 5-June infectious source, the letter can be sprayed 1:1:200 Bordeaux mixture. Rust disease in mid-May when the spray 0.2-0.3 degrees Baume or 25% of the debris flow mixture Triadimefon 100 times. There are diseases such as resin damage. Pests are brown, 7-October beetle infestation, young moth-eaten one tree trunk, Zhu Shi xylem, can be captured manually. Wind orange butterfly larvae Yaosi March buds, leaves, or biting into a notch and holes, can be sprayed Bt emulsion 300 times. Another aphid, red wax scale insect and other damage.

?Properties?

Fruit spherical character identification or slightly flat ball five angular diameter of 2-5mm. Surface dark green yellow to brown, rough, dotted with many points raised or sunken oil. The top of a five-pointed star-shaped cracks, the base of a calyx and stems, with yellow hair was. Hard and brittle. Gas rich aroma, pungent and bitter taste. With full, green color, aroma is preferred.

Microscopic Identification of fruit cross-section: round-like, the central divided into 5 rooms. Pericarp epidermal cells 1, class round, arranged in neat rows, most of the crystals containing hesperidin; most visible pores and a few non-glandular and non-glandular hairs off after the scars. Mesocarp thick, loose fibrous bundles and most large oil chamber, diameter 120-180?m, thin-walled cells containing clusters of calcium oxalate, near the fruit Pew dense clusters of crystal diameter 12-16?m. 4-5 out endocarp parenchyma cells, rectangular, cut to order, mesocarp cells than small. Each room has a fruit seed, TRIANGULAR, seed coat cells palisading stone, thick walls, are all within the endosperm seed coat tissue.

Powder characteristics: brown. ? non-glandular hairs 1-9 cells long and 62-350?m, wall warts clear that some cell-brown to reddish brown with things. ? 7-14 or more cells glandular head, oval-shaped, often with yellowish brown contents; handle 1-5 cells. ? clusters of calcium oxalate in diameter 10-25?m, sometimes square crystal. ? stalk round or rectangular stone cells, diameter 35-70?m, cell-large. ? oil chamber pieces are sometimes visible, pale yellow. ? hesperidin crystal fan or round, radial texture.

 

?Chemical Composition?

Seeds contain cis -5,8 – fourteen carbon II acid (cis-5 ,8-tetradecadienicacid). Volatile oil containing fruit Evodia ene (evodene), Evodia triptolide (evodol), limonoids (limonin). Fruit containing evodiamine (evodiamine), rutaecarpine (rutaecarpine), Evodia card product base (evo-carpine), hydroxyl evodiamine (hydroxyevodiamine), Evodia by alkali (wuchuyine), ocimene (ocimene), Evodia pyridine ketone ( evodione), Evodia fine (evogin), Evodia bitter elements (rutaevin), 7 – carboxy evodiamine (7-car-boxyevodiamine), dihydro rutaecarpine (dihydrorutaecarpine), 14 – rutaecarpine formic acid (14-formylrutaecarpine), 1 – methyl -2– nonyl -4 (1H) – quinolone [1-methyl-2-nonyl-4 (1H)-quinolone], N, N-dimethyl -5– methoxytryptamine (N, N-dimethyl-5-methoxytryptamine), N-methyl anthranilic acid amine (N-methylanthranoylamide), synephrine (synephrine), dehydrogenase evodiamine (dehydroevodiamine), Evodia amide (evodiamide), to the methyl amide Evodia [N-(2-methylaminobenzoyl) tryptamine], 6a-acid oxygen -5– table limonin (6a-acetoxy-5-epi-limonin), 6?-acetoxy -5– table limonin (6?- acetoxy-5-ePi-limonin), Treats ketone (obacunone), Dan Luo Mei lactide (jangomolide), Evodia bitter elements acetate (rutaevineacetate), Evodia tree lactide A (graucinA), 12a-hydroxy limonin ( 12a-hydroxylimonin), 12a-hydroxy Evodia triptolide (12a-hydroxyevodol), 1 – methyl -2 [(Z) -6 - November carbene] -4 (1H) – quinolone {1-methyl-2 [ (Z)-6-undecenyl] -4 (1H)-quinolone}, 1 – methyl -2 – [(Z) -10 - fifth carbene] -4 (1H) – quinolone {1-methyl-2- [(Z)-10-pentadecenyl] -4 (1H)-quinolone}, 1 – methyl -2 – [(Z) -6 - fifth carbene] -4 (1H) – quinolone {1-methyl-2 – [(Z)-6-pentadecenyl] -4 (1H)-quinolone}, 1 – methyl -2 – [(6Z, 9Z) -6,9 - fifth carbon diene] -4 (1H) a quinolone {1-methyl-2-[(6Z, 9Z) -6,9-pentadecadienyl] -4 (1H)-quinolone}, 1 – methyl -2 – [(4Z7Z) -4,7 - diene tridecane ] -4 (1H) – quinolone {1-methyl-2-[(4Z, 7Z) -4,7-tridecadienyl] -4 (1H)-quinolone}, Evodia fruit amide ? (goshuyuamide ?), Evodia fruit amide ? ( goshuyuamide ?). In addition, the fruit also contains aspartic acid (asparticacid), tryptophan (tryptophan), Thr (threonine), serine (serine), and cystine (cystine) and other eighteen amino acids.

Shi Hu containing Evodia fruit lactone (evodin), also known as limonoids (limonin), evodiamine, rutaecarpine, hydroxyl evodiamine, tigers A prime (Shih-HuA), Evodia card product base, dihydro Evodia card products alkali (dihydroevocarpine), 1 – methyl -2– undecyl -4 (1H) – quinolone [1-methyl-2-undecyl-4 (1H)-quinolone)], 1-methyl -2 – [(Z ) -6-- XI alkenyl] -4 (1H) – quinolone {1-methyl-2-[(Z)-6-undecenyl] -4 (1H)-quinolone}.

?Pharmacological effects

1. On the cardiovascular system:.

1.1. Cardiac function:.

1.1.1. The other eight isolated toad heart, Evodia soup with the same heart and cross to give isoproterenol. Evodia Decoction cardiac function suggest a small dose, long duration, no effect of isoproterenol accelerated heart rate, it may not increase myocardial oxygen consumption of the disadvantages.

1.1.2. 3 rabbits, weighing 1.75 ± 0.09kg, either sex. After anesthesia, the chest, caught with a frog heart clip the apex, mechanical electrical transducer connected to two physiological cardiac contraction curve were recorded. Ear vein to Evodia Decoction 0.3g/kg, observed for 30 minutes, followed by IV injection of 2% pentobarbital amount, to be significantly decreased myocardial contractility, the give Evodia soup, observed 30 minutes. Evodia Decoction seen in rabbits significantly enhanced cardiac contractility, 30 minutes after administration of drugs has not recovered to the level before.

1.2. Pressor effect:.

1.2.1. Dog 3, the plug-in blood pressure after anesthesia showed the left femoral artery blood pressure, and the right femoral vein to the Evodia soup 0.2g/kg. Blood pressure before administration was 13.29 ± 5.71 (kPa, X ± SD, the same below), increased blood pressure after administration, the peak was 24.36 ± 5.60, difference of 10.79 ± 1.24 (P <0.01); the lowest peak of 11.07 ± 5.41, difference of 2.20 ± 0.73 (P <0.05). Boost to maintain 368 ± 635; recovered was modest, to maintain 565 ± 95s.

1.2.2. Rat 9, in order to check pressure mercury right femoral vein was observed to 1.04g/kg Evodia Decoction injection on blood pressure, and heart rate by ECG tracings. Youyi 3 rats were observed 0.04mg/kg epinephrine effect on blood pressure, boost the role of the results of Evodia soup, before and after administration were significantly different (P <0.001), then take another six rats were divided into two groups . A set of predefined propranolol 1.8mg/kg, another set of phentolamine prior to 3.0mg/kg, 5 minutes after injection to Evodia Decoction 1.04g/kg. Results Evodia Decoction can raise blood pressure effects of phentolamine pre-treatment because of canceled; after the antihypertensive effect could be blocked by propranolol. These results show that the pressor effect of Evodia Decoction rapid heart rate associated with the slow step. ?, ? receptor blocking experiments showed that a significant Evodia Decoction excitatory effects of ?-and ?-excited weaker role for the ?, ? receptor mixed stimulants. As Evodia large amount of soup with ginseng, these experiments can not fully explain the pharmacological effects on cardiovascular Evodia.

1.3. On rabbit conjunctival microcirculation.

Rabbit 11, the back lying anesthetized on the operating table fixed to the insulation to 80 times magnification microscope, micro-circulation, cold light source observed conjunctival microcirculation. Ear vein slowly injected saline 0.3ml/kg, 5 minutes after bolus injection of Evodia Decoction 0.3g/kg, observe and take measurements before and after administration of arteriole diameter, capillary network exchange points, recording micro-flow state , Dynamic changes of red blood cell aggregation. After administration, the rapid increase in blood flow velocity slightly faster; part of the micro-state to improve blood flow, particle flow into a line of particle flow, particle flow into a line of flow lines.

2. The role of the digestive system:.

2.1. Anti-ulcer effect:.

2.1.1. On the impact of flooding stress ulcer: Take 50 male and female mice, body weight 21.2 ± 1.2g, were divided into 5 groups, 1 night of fasting, were administered Evodia Decoction, cimetidine and water, the stress into a special box, and immersed in 20-23 ? water to make the water level in mice and neck. Mice were killed after 8 hours, take the stomach, microscopic examination dot damage, bleeding points as the ulcer index calculated. 50% of oral 2g/kg methanol extracts, with anti-ulcer effect of raw water immersion in rats, inhibition rate of 66.6%.

2.1.2. Of the indomethacin, and the impact of ethanol-induced ulcers: Take 50 male and female mice, body weight 23.4 ± 1.9g, were divided into 5 groups, were administered after 24 hours fasting Evodia Decoction, furazolidone and running water. 30 minutes after the intraperitoneal injection of indomethacin 10mg/kg, l hour after intragastric 50% ethanol 0.2ml / only, get killed a few l-hour stomach, microscopic damage strip, measure the total length (mm) for the ulcer index. 20g/kg Evodia 10 and indomethacin were significantly inhibited ulcer formation caused by ethanol added.

2.1.3. Of hydrochloric acid gastric ulcer: 40 male and female rats, weight 176 ± 21g, were divided into 4 groups after 24 hours of fasting were fed with the extract of Evodia, cimetidine and water, l hours after the gavage 0.6N HCl 1ml / only, get killed a few l-hour stomach, microscopic damage strip, measure the total length (mm) for the ulcer index, the results shown in Table 8, Evodia 5 and were significantly 10g/kg inhibit the formation of hydrochloric acid ulcer.

2.1.4. Pyloric ligation ulcer on the impact of: 20 male and female rats, weight 145 ± 16g, sharing two groups, fasting 24 hours after pylorus ligation and ether anesthesia were injected in the duodenum Evodia Decoction and water, were killed 19 hours after suturing the abdominal wall to take the stomach, stomach ulcers before endoscopy, grade calculation index, the results shown in Table 8D. Tip Evodia 10g/kg only inhibit the tendency of ulcer formation.

2.2. On the secretion of gastric juice: the weight 240-300g of 20 male rats were randomly divided into two groups. Fasted 24 hours (free access to water), the treatment group by subcutaneous injection of Evodia weight 10g/kg soup injection. 2 times, of which l-hour intervals. Control group, normal saline the same method to other product. To the last 30 minutes, the animal anesthesia, suturing the abdominal wall after pylorus ligation. Fasting after water. 5h after the animals were killed to collect all the gastric juice volume and pH values ??were measured, and the determination of free acid and total acidity. The results show that the reduction of Evodia Decoction juice secretion in rats, and may reduce gastric acidity.

2.3. On gastrointestinal motility:.

2.3.1. Improve the gastric residual rate: body weight 18-22g 21 healthy mice were randomly divided into 2 groups, such as the method described by Zhang, residual rate of phenol red in the stomach as a row of rooms indicators, the faster emptying, gastric less residue, the results show that the Evodia Decoction can very significantly improve the gastric residual rate.

2.3.2. Suppression of isolated gastric strips: Preparation of isolated gastric section specimens, Tyrode’s solution maintained in an in vitro organ detector records the curve of gastric strips. Self-control by comparing before and after administration. Results When the maintenance of fluid concentration of single herb Evodia of 5 × l0 (-3) g / ml, Evodia Decoction concentration 1 × 10 (-2) g / ml, the section of the stomach showed an inhibition of spontaneous activity, tension and contraction amplitude is decreased, with the maintenance activities can be restored after washing liquid. Single herb Codonopsis, jujube, ginger, spontaneous activity of the stomach Article no significant effect on the acetylcholine induced contraction of stomach cramps article, single herb Evodia Evodia and significantly against the role of Tom, the performance of the tension and contraction rate of decline, the frequency decreased.

2.3.3. On a variety of drug-induced activity of isolated small intestine: about 1.5kg rabbits, guinea pigs 250g or so, according to warm-blooded animal experiments in vitro intestinal preparation and experiment, record the spontaneous contractile activity, to be given after a smooth intended to be against the drug (nicotine, physostigmine, acetylcholine, phentolamine, reserpine, sodium chloride and histamine), to be recorded contraction stabilized, given every 3 minutes 1 Evodia Decoction , a total of 3 times (except against acetylcholine and histamine is the use of a single dose outside), so that the nutrient solution showed three cumulative concentration of Chinese medicine, Chinese medicine each time to record 3 minutes after the change in bowel activity. That increase with the dose gradually Evodia display to 7 in vitro drug-induced inhibition of intestinal activity.

2.3.4. Antiemetic effect: Health pigeon 30, either sex, weighing 300-400g, were randomly divided into 3 groups of 10 each. Experimental group were given soup Evodia Evodia Decoction and the control group was given tap water, according to the same volume ig. L hour after administration, each fed 2% copper sulfate 1ml/100g pigeon body weight. Record every pigeon vomiting occurs first time (vomiting latency) and to the copper sulfate within 1 hour after the number of vomiting (vomiting frequency). Results Evodia Decoction could significantly reduce the frequency of pigeon vomiting, and vomiting, to extend the time required for the formation of the trend. There are some single herb Evodia antiemetic effect, but statistically not significant.

 

?Name? WúZh?Yú Pinyin

?English name? FRUCTUSEVODIAE

?Alias? Wu cornelian cherry, tea, hot, spicy, spicy smell, Miss Law, smelly paozi

?Source? This Rutaceae Evodia Evodiarutaecarpa (Juss.) Benth., Tigers Evodiarutaecarpa (Juss.) Benth.var.officinalis (Dode) Huang or thinning hair Evodia Evodiarutaecarpa (Juss.) Benth.var.bodinieri (Dode ) Huang dry nearly ripe fruit. 8 November when the fruit has not cracked, cut fruit branches, dried or low temperature drying, remove the branches, leaves, stems and other impurities.

?Properties? This product is spherical or slightly flat ball five angular diameter of 2 ~ 5mm. Surface yellowish green to brown, rough, there are many point-like protrusions or sunken oil point. The top of a five-pointed star-shaped cracks, the base is a yellow residue hairy stems. Hard and brittle, can be seen cross-section of ovary 5 rooms, each room has a yellow seed. Gas rich aroma, pungent and bitter taste.

Identification? ?

(1) This product powder brown. 2 ~ 6 cells in non-glandular hairs, long 140 ~ 350?m, wall warts clear that some cell-containing material brown to reddish brown. 7 to 14 cells glandular head, oval-shaped, often with yellowish brown contents; handle 2 to 5 cells. More clusters of calcium oxalate, diameter 10 ~ 25?m; occasional side crystal. Round or rectangular stone cells, diameter of 35 ~ 70?m, cell-large. Oil chamber pieces sometimes visible, pale yellow.

(2) to take this product powder 0.5g, adding hydrochloric acid solution (1 ? 100) 10ml, shake vigorously for several minutes, filtration. Take filtrate 2ml, potassium iodine test solution 1 drop of mercury, after shaking, the resulting yellow-white precipitate; In another filtrate 1ml, slowly adding the test solution of dimethylamino benzaldehyde 2ml, heated on a water bath, the two liquid junction generated at the reddish-brown ring.

?Content?

High performance liquid chromatography (Appendix ? D) determined.

Chromatographic conditions and system suitability testing octadecyl silane bonded silica as a filler; acetonitrile – water – THF – acetic acid (51:48:1:0.1) as mobile phase; the detection wavelength was 225nm. Number of theoretical plates Evodia amine peak should not be less than 7000.

Preparation of control solution amine Evodia accurately weighed, rutaecarpine appropriate reference substance, add methanol were made each containing 0.1mg per 1ml of solution, that is, too.

Preparation of the test solution powder of this product (over ?? screen) about 0.13g, accurately weighed, add methanol 80ml, heat reflux for 50 minutes, let cool, filter, filtrate recycling to the amount of methanol, transferred to a 10ml volumetric flask , add methanol to the mark, shake, that is, too.

Determination of precise drawing of the two respective control solution and test solution of the 5?l, into the liquid chromatograph to measure, that is, too.

This product contains Evodia amine (C19H17N3O) and rutaecarpine (C18H13N3O) the total amount of not less than 0.20%.

? ?Processing

Evodia: remove impurities.

Evodia system: Take licorice broken, plus adequate water, Jiantang, to Java, to join the net Evodia, moistening exhaustion, the stir-fry until slightly dry, remove and dry. Evodia per 100kg, with licorice 6kg.

? ?Taste acrid, bitter, hot; a small drug.

? ?Go through the liver, spleen, stomach, kidney.

?Indication? and cold pain, Jiangni vomiting, diarrhea yang. Jue Yin for headache, abdominal pain, Han Shan, alpine athlete’s foot, the line of abdominal pain, abdominal pain, bloating, vomiting Tunsuan, Diarrhoea, external treatment ulcer; hypertension.

Dosage 1.5 ~ 4.5g; external use.

?Storage? Store in cool dry place.

Extract? ?”Chinese Pharmacopoeia”

Evodia “* Dictionary”

?Source? “The Classic”

?Name? WúZh?Yú Pinyin

?Alias? Wu cornelian cherry (“vegetation, the party”), the left edge (“materials Nanning thistle Chi”).

?Source?

Rutaceae Evodia for the immature fruit. 8 to 10 months, the fruit was green tea, but when the harvest not yet separated carpels. Off and dried to remove impurities. In case of rain, dry with a micro-kang.

In addition to these species, there are tigers and the same plants such gross clock Evodia unripe fruit, also applies to other use.

? ?Original form

Evodia, also known as: Spicy, spicy smell the tree, gas spicy, starter sub, spicy tea.

Evergreen shrub or small tree, 2.5 to 5 meters high. Shoots, leaf axils, small petiole are densely brown villous. Odd pinnate, opposite; leaflets 2 to 4 pairs, elliptic to ovate, 5 to 15 cm wide and 2.5 to 6 cm, apex mucronate, acute tip, rarely acuminate, base cuneate to rounded , entire, rarely obvious round serrated on both sides densely yellow villous, thick paper or paper, with oil spots. Flowers unisexual, dioecious, inflorescence, even into a cone shape, the top students; the base of rachis bracts 2, the upper bracts scale-like; flowers small, yellow-white. Sepals 5, wide oval, lateral Phi dense yellow pubescent; petals 5, oblong, densely inside the white villous; male with stamens 5, longer than the petals, anther base with an oval, silk coat, a little degradation of the ovary into a triangular shape, hair, tip 4 to 5 cleft; larger female, with staminodes 5, scaly, ovary superior, round, carpels usually 5, chunky style, stigma head-like, flat capsule spherical, long about 3 mm, 6 mm in diameter, purple when ripe, the surface of glandular dots, each carpel with one seed, oval, black, shiny. Flowering 6 to 8 months. Fruit of the 9 to 10 months.

The roots of the plant (Evodia root), leaf (Evodia leaf) also for medicinal purposes, the details of special articles.

?? Wildlife habitat distribution in the mountain, street or sparse woods. Distributed in the basin and southern China long carry and Shaanxi. Main Guizhou, Guangxi, Hunan, Yunnan, Shaanxi, Zhejiang, Sichuan and other places.

?Properties? dry fruit was flat five prismatic sphere, diameter of 2 to 5 mm, height of about 1.5 to 3 mm. Surface green or green-brown, rough, with fine wrinkles and eye bristles (oil chamber); the top level, the middle of pit and 5 cracks, sometimes there are cracks in the central protuberance of the stigma left over from the base of the calyx and stems, stems square circle, length 3 mm, brown-green, fluffy clouds. Cross-section of ovary 5 rooms, each room has yellow seed 1 to 2. Oil-rich seeds, hard and brittle. Strong aroma, bitter slightly pungent. The color green, full preferred.

?Chemical Composition?

Evodia Evodia fruit contains volatile oil is allyl, ocimene, Evodia lactone, Evodia lactone alcohol. Also containing Evodia acid. Also contains alkaloids: evodiamine, rutaecarpine, Evodia by alkali, hydroxyl evodiamine, Evodia card product base. Evodiamine ethanol with hydrochloric acid that is converted into different evodiamine. Also containing two neutral non-nitrogenous compounds: pyridine ketones and Evodia Evodia fine. And with bitter Evodia factor.

Lactone containing Evodia fruit Shi Hu evodiamine, rutaecarpine, hydroxyl evodiamine. Still contain unsaturated ketone, tentatively called tigers A prime, essential oil, color glycosides and steroid compounds.

?Pharmacological effects

? piperazine citrate effect

Evodia alcohol extract of Ascaris suum in vitro have a more significant role; on earthworms, leeches are also effective.

? antibacterial

Evodia Decoction (100%), Vibrio cholerae has a strong inhibitory effect (agar plate method trenching). 10% of the flooding agent for in vitro inhibit Epidermophyton floccosum; 1:3 flooding agent on the Audubon Ang’s 11 kinds of small spores skin fungus Trichophyton different degree of inhibition.

? central role

Evodia has a lot of excitement on the central role, and can lead to visual impairment, delusions and so on. Japan has produced ethanol extract of Evodia analgesic effect, with proof of rabbit tooth pulp electrical stimulation, 10% ethanol extract of intravenous injection of 0.1 to 0.5 ml / kg of analgesic effect. Intravenous injection of 0.2 ml, analgesic efficacy and safety for the aspirin or aminopyrine (each with 2 ml of 1%) roughly equal. In the cold, is stronger than the two drugs. 0.1% difference Evodiamine hydrochloride 0.1 to 0.5 ml / kg, is also analgesic effect in rabbits; 1 to 2 ml / kg of body temperature slightly increased the rabbit. Single species with 10% ethanol extract of Evodia 0.5 to 2.0 ml of rabbit body temperature can also rise. From another species EvodiaxanthoxyloidesF.Muell made Evodia alkaloids, the hydrochloride salt has sedative and hypnotic effects in mice, but the rats decreased body temperature, but also against the camphor in rats or mice induced convulsions role.

? other roles

Evodia is 10% ethanol extracts of plants, to the rabbits injected with 0.5 to 1.0 ml, short and slight blood pressure increases, breathing mild excitement, increased carotid blood flow. 0.1% difference Evodiamine hydrochloride 0.2 to 0.5 ml / kg intravenously, no significant changes in rabbit blood pressure, breathing a little increase; with 0.02 ~ 0.1% effect on isolated frog heart was not obvious, frog leg vascular bed, are generally not significant , after the first, the expansion contraction; on isolated rabbit intestine, the beginning of a short period of excitement, after the paralysis; on the isolated rabbit house, start a stimulant. Evoxine low toxicity in mice the median lethal dose, subcutaneous injection of 705 mg / kg, intravenous injection of 135 mg / kg. Evodia ingredients, such as Evodia lactone, evodiamine, rutaecarpine different evodiamine similar analgesia, increased body temperature, a slight influence on respiration and blood pressure. Rutaecarpine rue alkali decomposition product of a strong uterine contraction. Evodia base in mice by anti ColumbiaSK virus.

Obtained from the E.xanthoxyJoides in alkaloids, and the Yin line base similar to the role of epinephrine can enhance and improve the excitability of spinal reflex, relaxation of intestinal smooth muscle, striated muscle tension increased, in some respects the role of ephedrine similar.

? ?Processing

Evodia Sunburn: Take licorice decoction, to Java to take soup, added a net Evodia, soaking liquid to the dry soup for the degree, Wei Huo drying. (Per Evodia 100 pounds, 6 pounds 4 with two licorice)

? “Tong Xuan Materia Medica”: “Evodia, salty soup dipping sauce to go strong, for drying water.”

? “Materia Medica truth”: “Evodia Chen are good, strong bubble to the bitter sauce. Antiemetic Coptis fried, fried salt hernia treatment, treatment of blood Cuchao.”

? ?Taste

Hard, temperature, toxic.

? “The Classic”: “spicy, warm.”

? “Do not Catalog”: “hot, a small drug.”

? “medicinal theory”: “bitter, acrid, hot, toxic.”

Meridian? ?

Hepatic, stomach.

? “Herbal Decoction”: “into the full moon, Shao, Jue Yin Meridian.”

? “concocted herbal solutions Thunder”: “hepatic, spleen, stomach, large intestine, kidney.”

?Indication?

Temperature, the pain, qi, dampness, cure vomiting inverse Tunsuan, Jueyin headache, dirty winter vomiting and diarrhea, abdominal pain, bloating, abdominal pain, through the line, just before dawn, diarrhea, hypertension, beriberi, hernia, aphthous ulcers, tooth pain, eczema, sore yellow water.

? “The Classic”: “the main lower temperature gas, pain, Keni cold and heat, dehumidification blood weakness, by Feng Xie, open Cou.”

? “Do not Catalog”: “Lord of cold phlegm, abdominal cramps, cold reality Needless to all, the evil, heart pain, reverse air, Lee five internal organs.”

? “medicinal theory”: “Lord confidant disease, plot the cold, the heart under the knot gas, Zhu heartache; treatment of cholera transferred tendons, stomach air-conditioning, abdominal pain, vomiting and diarrhea can not win the ninja; treatment Bianshen stubborn weakness, cold Needless, Lee colon owned gas . ”

? “Herbal Supplements”: “kill the evil worm virus, worm hiding teeth.”

? “Japan Hanako Materia Medica”: “spleen through joints. Treatment of abdominal pain, kidney, beriberi, edema, lower than postpartum blood.”

? Wang Hao Gu: “Cypriot government fullness chest, pharynx diaphragm barrier, run dry liver spleen.”

? “outline”: “Gloomy of stagnation. Rule Tunsuan, kick, hold the spit yin headache, insidious abdominal pain, hernia, Campylobacter, mouthpiece of the ulcer.”

Dosage Oral: decoction, 0.5 ~ 2 money; or into pills, powder. External: steaming hot iron, deposited or transferred into powder and fried Washed.

?Note?

Yin Huo-wang, who Jifu.

? “Annotations of Materia Medica”: “Polygonum real worth to make. Bad Salvia, elimination stone, chalk, fear of amethyst.”

? “Ben Cao Meng Quan”: “false intestine, especially those who avoid leakage.”

? “outline”: “Go Air, Hot, faint eyes, hair sore.”

? “Ben Cao Jing Shu”: “vomiting, stomach fire Tunsuan is who should not use; Keni on the gas, and non-cold evils and cold due to phlegm places who should not use water; abdominal pain is a deficiency of blood and fire who should not use; Chibai diarrhea due to summer heat evil into the stomach, rather than the food and drinks cold, stagnant fouling who should not use; intestinal hernia, non-sudden sense of cold evil, and the initial issuance of one or two who should not use; cholera transferred tendons, due to the weak spleen and stomach to take summer cause, rather than damp cold in the guilty who should not use the stomach; all the Yin of the card and the internal organs were hot without cold, avoid salty law. ”

? ?Attached side

? ? on kidney treatment, kidney from the abdomen from the building in the throat, against the gas is not even spit, or to dozens of sound, may not break down: Evodia (Cuchao), orange peel, tuber (peeled) the one or two. For the end of the batter pills, Wu Zi Grand. Under seventy per pill ginger. (“Ren Cun Tong experience side”)

? governance vinegar heart, such as strong that each of vinegar, vinegar gas upside: a co-cornel. Water three, fried seven, Dayton clothing. Vertical concentration, also strong suit. (“Ministry of War offering hand side”)

? governance has Tunsuan food, stomach Qi cold by: Evodia (soup bubble seven, baking), ginger (gun) decile. To the end, Tom served a penny. (“Sheng Hui Fang”)

? governance anger: Coptis sixty-two, Evodia twelve or half-two. For the end of the water pills, or Zheng Bing pills. Decoction next fifty pills. (“Danxi Heart” left Kanemaru, a return to that pill)

? vomiting and chest full of governance, and dry Xianmo vomiting, headache: Evodia a liter, thirty-two ginseng, ginger sixty-two, date twelve. On the four flavor to five liters of water, Zhuqu three liters, warm clothes seven together, day three. (“Golden Chamber” Evodia Decoction)

? rule head wind: Evodia three liters. Five liters of water, Zhuqu three liters, the cotton swab hair. Roots. (“Dry Gold Wing Party”)

? back rule phlegm cold headache, vomiting and acid juice, V pillows do not eat for several days, the 10th first serve: Evodia (soup bubble seven), Poria raise points. For the end of Wu Zi Grand refining pill. Fifty per pill under hot water, (“Chu set prescription”)

? rule for many years to vent spleen, the elderly more than this, that the assimilation of water and soil: Evodia three money. Dip, Jian Zhi, into a little salt, oral communication, cover cornel to warm the bladder, both waterways clean, large intestine from the solid, other medicines, although hot, can not break voicing too. (“Ren Cun Tong experience side”)

? Spleen by moisture to vent more than Lee, late of rice, umbilical abdominal tingling; gas diarrhea in children with malnutrition, also rule: Coptis (to be), Evodia (remove the stem, fried), all five ounces of white peony. For the fine, the batter for the pill, such as the Indus child large. Twenty per serving balls, fried rice drink strong, hollow at three. (“The Council” Wuji Pills)

? rule beriberi Rufu, sleepy nausea mortals Sugar Lee, abdominal distension: Evodia six liters, papaya and two (cut). The two flavor to three liters of water a bucket, Zhuqu three liters, divided three, quite different, such as pedestrian miles long, into one, or spit, or sweat, or profit, or hot bored, or recover from illness. (“Qian” Su Eliot cornel soup)

? athlete’s foot pain treatment, such as human influenza rheumatoid streamer, can not tolerate foot foot pain, swollen tendons He should take it: seven betel nuts, dried tangerine peel (to white), papaya, and one each in two, Evodia, basil leaves all three money, bellflower (to Lo), ginger (and skin) half and half two. On fine-cut, decoction, just before dawn the next day, divided into three, five, but the cold service. May also slightly warm clothes in winter. (“Treatment of the criterion” Bordering bulk)

 

Recently, much of the small intestine ? hernia treatment, migraine pain fall twitch, summarized below the belly button pain, nausea resulting chaos, and external hard renal swelling, increasingly grow, itchy as hell wet sores: Evodia (to the rachis) pound (four dual-purpose wine Baptist, four dual Vinegar, four dual-soup dip, four dual-boy urine dip, dip each night, with the drying), Alisma (to dust) two two. For the fine, Jiuzhu batter Wanru Indus child large. Fifty pills per serving, hollow salt soup before eating or swallowing the wine. (“The Council” deadly Dan)

? reduction of infant kidney (the primary exposure to cold is due): Evodia, sulfur, two half and half. Painted their bellies with garlic research, Cnidium still smoked it. (“Sheng Hui Fang”)

? mouth ulcer treatment Malnutrition: Cornel end of the transfer coating Zuxin vinegar. Also rule throat ached. (“Jane side near Lake Set”)

? treatment dental pain: cornel gargle of fried wine. (“Herbal”)

? treatment eczema: a couple of fried Evodia, cuttlefish bone seven money, sulfur II money. Joint research to fine alternative. Eczema lesion exudates were sown more than dry; those with no exudate of castor oil or pork suet adjuster to wipe, every other day, after treatment with gauze bandage on. (“Selected full expansion of Dermatology”)

? yin itchy sores the wet: Evodia a liter, three liters of water, cook three to five boiling, to sediment to wash sores. Also rule all sore. (“Ancient recorded prescription”)

? stroke (mouth deflection, not language). By cornel a liter, three liters ginger soy, sake five programs, decoction open several times, half a liter per serving after cooling. Three times a day. Weihan Jiyu.

? itch. By cornel a liter, five liters plus wine, boiled a liter and a half, by temperature scrub, itching will stop.

? feeling cold winter months. Evodia decoction with five money services to sweat for the degree.

(21), vomiting, chest full, headache. One liter with cornel, dates twenty, one or two of ginger, ginseng or two, add five liters fry three liters of water, each serving seven together, serving the second day, the party name “Evodia soup.”

(22) confidant Leng Tong. Evodia together with five, plus three liters of wine, boil, three times serving.

(23) small intestine hernia (partial fall of pain, testicular swelling hard, wet pussy itch.) With Evodia (remove the stem) a pound, divided into four. Four ounces sparkling wine, four ounces hot vinegar, four ounces hot water, four ounces bubble Tongbian. The night after they have been out for drying, Jiaze diarrhea twenty-two of research for the end of the wine and powder transfer into balls, such as Wu Zi Grand. Fifty pills per serving, Kong Xinfu, salt, wine, soup or send the next. This side name “killer Dan”, Yiming “stars pill.”

(24) Women’s chill, eventually becoming pregnant. With Evodia, Chuanjiao each one liter of research for the end, plus refining honey balls to do, such as marbles big. Meat wrapped in cotton into the vagina, uterus so that pregnancy can be opened.

(25) stomach qi deficiency and cold vomit acidic water. Evodia soak in boiling water with seven, drying out, add ginger (guns), and so divided at the end. A penny per serving, soup deliver it.

(26) transferred tendons Rufu. By Cornel (fried) Second of two plus wine, two bowls, fry a bowl, at the second service. Have diarrhea Jiyu.

(27) years old water leakage. Evodia three with money, dip, remove, add water to cook anger, put a little dose of salt.

(28) red white diarrhea (stomach by the wet, diarrhea, abdominal pain, not of rice.) With Evodia, berberine, white peony and one each in two to fry for the end, add Zheng Bing made of balls, such as the Wu Zi Grand. Each serving twenty or thirty pills, sent under rice soup. This side name “Wuji Pills.” Another side: The Second Canyon River berberine, Evodia twenty-two (Tang Qin seven), with the fry, respectively, for the end of study, each with balls made of corn meal, such as the Wu Zi Grand, store backup. Thirty pills per serving. Dysentery, with delivery service Coptis Decoction pills; white diarrhea, dry ginger pills delivery service cornel; red white diarrhea, with fifteen of the two pills, get under rice soup. This side name “alternative pill.” Another side: with Evodia twenty-two, berberine twenty-two with saute for their own end. By Bai Caoshuang twenty-two, rice balls made with berberine; to TGP Yaomo twenty-two, rice balls made with dogwood, all as Wu Zi Grand, store backup. Fifty pills per serving. Dysentery, with dark plum soup with cream pill delivery service; pullorum to rice soup delivery service June is peony pill; red white diarrhea, two pills each serving twenty-five. The party name “two-color balls.”

(29) belly plot block. Mash with a liter of cornel, and wine cook, remove the iron product in a soft cloth bag at the block, cold iron is sizzling again. Blocks such as mobile, iron is also moving, until the plot block removed.

(30) Dental pain. Cornel fried with wine rinse.

(31) families to rubella. Cornel fried with wine Tucha.

(32) ulcer hair back. Pound with one liter for the end of Evodia, plus bitter tone posted coating the affected area.

(33) chills and fever strange disease (chills fever more than a few days after the limbs as hard as stone, bronze knocking sound made up, growing thin.) By Cornel, woody decile, fried inspired clothing.

Clinical? ?

? Treatment of Hypertension

Will Evodia into powder, each taking two of 0.6 to 1, with two Zuxin deposited Vinegar (preferably before going to bed dressing, wrapped with a cloth.) Generally apply 12 to 24 hours after the blood pressure began to decline, reducing symptoms. Mild deposited 1, weight deposited 2 to 3 times the antihypertensive effect is displayed.

? indigestion

Wu cornelian cherry powder to take 2.5 to 3 grams, 5 to 6 ml with the vinegar into a paste, heated to 40 ?, stand at the 2 square gauze layer (about 0.5 cm thick), since the 4 series of setbacks; affixed to the umbilical Department, with plastic sheets fixed. 12-hour replacement 1. The treatment of 20 cases, 18 cases cured, improved in 1 case, 1 patient. Preliminary observations of this Law regulating gastrointestinal function, temperature and go cold, pain, and help digestion and so on. Dysfunction of the stomach caused by diarrhea Cheong better for diarrhea caused by bacterial infection with the application of antibiotics can produce synergy.

? treatment of eczema, neurodermatitis

Evodia into powder, using Vaseline tune into 30% (Class A) and 20% (B) of two ointment; then take 30% of Evodia cream and mix thoroughly equal amount of zinc oxide ointment, dubbed the compound Evodia ointment (C species). Of subacute and chronic eczema general, and scrotum eczema or early in the subacute stage by using the B ointment; chronic scrotal eczema for many years a kind of cream is applied; baby eczema ointment by gamma. Local paint medicine 2 times a day. A species of Neurodermatitis cream paint first, then with the hot hair dryer, day 1, every 20 minutes, then slightly larger than the lesions of tape affixed to prison block. 82 patients with eczema and neurodermatitis, according to the observation of the early and subacute eczema Eczema is better, shorter healing time member of 3 days; on general chronic eczema, heal the shortest, 10 days; for many years was chronic lichenification Eczema is invalid; 11 cases of infantile eczema, in addition to two cases invalid, the remainder were clinically cured 7 to 15 days; scrotum eczema obvious initial effect, the sick the past years is void in the moss-like change; neurodermatitis 19 patients, both light Bureau of patients and limited, with the hot hair dryer than a simple applicator by a significant effect. Evodia another paste with 10% topical cream, and then the AI ??smoked for 20 minutes, limited treatment of neurodermatitis Board 14; were cured in 4 cases, significant improvement in 7 cases, improved in 3 cases. General treatment to cure patients 4 to 6 times. This method antipruritic effect is remarkable.

Treatment of yellow water sore ?

Evodia research will be modulated into a powder with Vaseline ointment 10%, partial erasure, 1 or 2 times a day. Cayao wash the affected area with warm water before: treatment of 12 cases, usually 4 to 6 times Jiyu.

? treatment of oral ulcers

Will Evodia broken, screening, take a good amount of vinegar added to fine tune into a paste, applied to the gauze, the Fuyu bilateral Yongquan, removed after 24 hours. Dosage: 1 to 2 years of age with 0.5 money, 1 to 5 years of age with 2 to 3 money, from 6 to 15 years old with 3 to 4 money, 15 years old with 4 to 5 money. Treatment of 256 cases, 247 were cured. 1 is generally treated effectively.

?Remarks? Evodia effect is warm, the cold, under the gas, open-Yu. Clinical practice in recent years, in fact, the FDA rule also enterobiasis. Evodia learn that clinical practice has obvious pain, vomiting effect.

Extract? ?”* Dictionary”

Evodia “Chinese Materia Medica”

?Source? from “Shen Nong Ben Cao Jing.”

?Name? WúZh?Yú Pinyin

?English name? MedcinalEvodiaFruit, FruitofMedicinalEvodia

?Alias? Wu cornelian cherry dogwood food, tea, hot, paint Spicy, excellent spicy, starter sub, gas Spicy.

?Source?

Medicine-based source: Rutaceae Evodia, tigers and immature fruits of Evodia gross veins.

Latin name of plant and animal fossil: 1.Evodiarutaecarpa (Juss.) Benth.2.Evodiarutaecarpa (Juss.) Benth.var.officinalis (Dode) Huang3.Evodiarutaecarpa (Juss.) Benth.var.bodinieri (Dode) Huang

Harvesting and storage: 3 years after transplanting, early maturing varieties in early July, late-maturing varieties early in August, green tea, which was to be the fruit carpels Weifen Li when harvested, picked before the dew was dry the whole string of ear, not to pick off fruiting branches, dried, hand rub, the stalk off, cleanse. In case of rain, with Weihuo anti-dry.

? ?Original form

1. Bark grayish green, young branches purplish brown, with small circular lenticels; immature technology, leaf axils and flowers are rust-colored hair shaft. Odd pinnate compound leaves opposite, with petiole length 20-40cm; petiole length 4-8cm, the small petiole length 2-5mm; leaflets 5-9, elliptic to ovate, 5.5-15cm, Width 3-7cm, tip suddenly narrow into a short, base cuneate to a broad wedge-shaped or circular, entire or with indistinct blunt teeth, lateral veins not obvious, both sides are light brown villous, especially on the veins more obvious point of oil , thick paper, or paper. Dioecious, polyethylene umbrella panicles, the top students; rachis stout, densely brown pilose, the base of leaf rachis narrow sheet opposite bracts 2; sepals 5, wide oval, about 1 -2mm, pubescent; petals 5, white, oblong, 4-6mm; male flowers with 5 stamens, born in the tiny flower disc inserted, the anther base with an oval, with short filaments, wool, degradation ovary apex 4-5 split; female than male petals petals large, scale-like staminodes, ovary superior, oblong, carpels 5, widened into a flat circle after flowering, with thick glandular dots, chunky style stigma 4-5 money crack tip. Flat spherical fruit, ripe fruits split into five valves, showing follicle-like fruit, purple, thick surface oil glands, and every fruit with seeds 1 sub, black, shiny. Flowering from June to August, the fruit of 9-10.

2. Tigers are species of this variety is very similar. Different point mutation has a special pungent odor. Leaflets 3-11, leaves narrower, oblong to narrowly lanceolate, apex acuminate or long acuminate, more distant away from the small blade, lateral veins obvious, entire, densely villous on both sides, and the pulse of the most dense, thick oil glands. Rachis often pale yellow or colorless villous. Species of mature fruit is not as dense sequence. With blue-black seeds. Flowering July-August, the fruit of 9-10.

3. Evodia and on the kinds of hair similar vein. Branchlets are rusty or yellow silk quality sparse long hairs. Rachis were villous; leaflets 5-11, leaf shape changed greatly, oblong, lanceolate, ovate-lanceolate, slightly on the surface of the vein was sparse short hairs, the following veins pubescent, lateral veins clear, a small oil glands. Flowering July-August, the fruit of 9-10.